According from the studies done in Canada, the cranberry extract can prevent colon cancer through anti-inflammatory mechanism.
As stated in the Journal of the Science of Food and Agriculture, Richard Narayansingh and Robert Hurta from the University of Prince Edward Island, oily extract of cranberry and quercetin, which is a major cranberry flavonoid, can reduce inflammation processes related in colon cancer.
“Our results are the first to suggest a possible mechanism involved in anti-cancer activity of the oily extract of cranberry and quercetin is partly through its anti-inflammatory action,” wrote Naravansingh and Hurta.
Colorectal or colon cancer is the third most commonly diagnosed cancer in the United States, according to the American Cancer Society. About 150 000 new cases are diagnosed annually in the US (with between men and women almost 50-50).
Researchers from Canada performed a lab study using cells from human colon adenocarcinoma type HT-29 which they treated with different doses of cranberry oil extract or quercetin. Expression of cyclooxygenase-2 (COX-2) enzyme, which is associated with the inflammatory process, was measured sequentially together with other substances.
Narayansingh i Hurta show that the cranberries extract and quercetin decreased the expression of COX-2. Moreover, the researchers noticed a decrease in the expression of COX-2 in cells stimulated with a compound that promotes the growth of tumors.
“These findings are important because they demonstrate that the F-kB signaling pathway provides a possible link between inflammation and cancer and anti-inflammatory properties of oily cranberry extract or quercetin can be used to modulate these pathways,” the researchers write. “Future studies of in vivo models of colon cancer to be made in the near future,” they concluded.